We’re committed to our mission of finding new treatments that may help improve the lives of people with cancer. Our clinical trials for colorectal cancer study investigational medications alone, or in combination with other study medications, or standard of care therapy. We perform these trials to see if they can help prevent, find, or treat cancer.

Colon and rectal cancers (also known as colorectal cancer) begin as polyps, which are abnormal growths inside the colon or rectum. If not removed, these polyps may become cancerous. Stage IV, or advanced colorectal cancer, means that the cancer cells from the colon or rectum have spread to other parts of the body.

Microsatellite instability (MSI) in colon and rectal cancer

In order to properly plan your treatment, your doctor may want to know if your cancer cells are microsatellite instability-high (MSI-H). In most people, proteins known as MMR (mismatch repair) correct errors in the DNA. However, in some people with colorectal cancers, the genes that form the MMR proteins are defective and this can make parts of the DNA unstable, which is known as a deficient MMR (dMMR) system. Tumors that have a dMMR system can develop microsatellite instability (MSI).

There is a lot to consider when deciding whether to participate in a clinical trial. Any clinical trial includes risks, which the study doctor will review with you. Make sure you understand the risks before participating.

You can also call our clinical trial information center at 1-888-577-8839 to learn more.

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Status

Recruiting

Trial ID

MK-3475-158

Clinicaltrials.gov

NCT02628067

Keynote Oncology Clinical Trials

Nearest Location

12.49 miles

Condition

Vulvar Carcinoma, Advanced Cancer, Advanced Solid Tumors, Anal Cancer, Anal Carcinoma, Bile Duct Cancer, Biliary Cancer, Carcinoid Tumor, Cervical Cancer, Cervical Carcinoma, Cholangiocarcinoma, Colorectal Carcinoma, Endometrial Cancer, Endometrial Carcinoma, Mesothelioma, Neuroendocrine Tumor, Parotid Gland Cancer, Salivary Cancer, Salivary Gland Cancer, Salivary Gland Carcinoma, Small Cell Lung Cancer, Small Cell Lung Carcinoma, Thyroid Cancer, Thyroid Carcinoma, Vulvar Cancer

Phase

Phase 2

Status

Recruiting

Trial ID

MK-9999-02A

Clinicaltrials.gov

NCT06428409

Lightbeam Adult Clinical Trials Logo-Final

Nearest Location

17.06 miles

Condition

Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer, Colorectal Cancer

Phase

Phase 1, Phase 2

Resources for patients

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About clinical trials

Learn what clinical trials are, how they work, and if you may be eligible to participate.
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